Synthesis of Indolizine Derivatives and Their Reactions

One-pot Synthesis of Polysubstituted Indolizine Derivatives

An efficient approach to the synthesis of 1,2,3-trisubstituted indolizines is described via one-pot reactions of pyridine and dialkyl acetylendicarboxylate in the presence of ethyl 2-chloroacetoacetate in MeOH at room temperature. The corresponding 1, 2, 3-trisubstituted indolizines may be useful building blocks for the construction of complex indolizine derivatives.

Synthesis of Phosphorus Derivatives via Multicomponent Reactions

Stable derivatives of oxaphosphaphenanthrenes were prepared using multicomponent reactions of 3-bromo-2-naphthol, dialkyl acetylenedicarboxylate and trimethyl or triphenyl phosphite under microwave conditions with good yields. 

Synthesis and Reactions of Triptycenes and Their Derivatives

In order to verify if the triptycyl (the analog of triphenylmethyl in which the three phenyl groups were united to a CH) free radical 1a (Fig. 2.1) should be more instable than the triphenylmethyl radical itself, Bartlett et al. [1] first synthesized triptycene 1 in a low total yield by a multistep route starting from the Diels–Alder addition reaction of anthracene and benzoquinone (Scheme 2.1)...

Ultrasound-assisted 1,3-dipolar cycloaddition and cyclopropanation reactions for the synthesis of bis-indolizine and bis-cyclopropane derivatives.

Ultrasound irradiation can promote the 1,3-dipolar cycloaddition reaction of 2-chloropyridinium ylides with 2-benzylidenemalononitrile or 2,2'-(1,4-phenylenebis(methanylylidene))dimalononitrile, to afford the indolizine and bis-indolizine derivatives respectively. While the reaction of pyridinium ylides with 2-benzylidenemalononitrile or 2,2'-(1,4-phenylenebis(methanylylidene))dimalononitrile u...

synthesis of phosphorus derivatives via multicomponent reactions